Speedball, powerball, or over and under[1] is the polydrug mixture of a stimulant with a depressant, usually an opioid. The most well-known mixture used for recreational drug use is …

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3 days ago · A speedball is a dangerous mix of a stimulant (most often cocaine) and a depressant (most often heroin or another opioid). This combination is especially risky because the …

Mar 14, 2025 · A speedball is a combination of a stimulant (usually cocaine or methamphetamine) and a CNS depressant (typically an opioid), used simultaneously to produce an intense and …

Dec 2, 2024 · A speedball is a combination of heroin and cocaine taken intravenously. It can cause harmful effects and requires treatment to manage addiction.

A speedball is a combination of heroin and cocaine that is usually injected, snorted or smoked. The high produced by the stimulant effect of cocaine combined with the depressant effect of …

Apr 17, 2025 · What Is a Speedball? A speedball is a combination of a stimulant (commonly cocaine or methamphetamine) with an opioid (frequently heroin, but also fentanyl, morphine, …

Oct 19, 2025 · A speedball is a dangerous combination of a stimulant drug, such as cocaine, and a depressant drug, most commonly heroin. The two drugs have opposite effects on the body, …

Sep 10, 2025 · A speedball is a combination of 2 strong and potentially lethal substances: heroin and cocaine. This deadly mix of uppers and downers is often prepared by mixing powdered …

Dec 2, 2025 · A “speedball” refers to combining two substances with opposing effects: a stimulant and a depressant. The classic mixture involves cocaine, a central nervous system (CNS) …