May 24, 2025 · Inhibiting LIF could suppress proliferation and metastasis by activating p38MAPK/p62-modulated mitophagy. Interestingly, we found that the natural small-molecule …

May 24, 2025 · In summary, we identified LIF as a tumor promoter in HCC and systematically investigated its oncogenic role in facilitating cancer cell growth and metastasis by modulating …

Here, we identified LIF as a potential biomarker and druggable target in HCC, as it inhibits HCC through the LIF/p38MAPK/p62 pathway, an unreported pathway in HCC tumorigenesis.

Inhibiting LIF could suppress proliferation and metastasis by activating p38MAPK/p62-modulated mitophagy. Interestingly, we found that the natural small-molecule Cyclovirobuxine-D (CVB-D), …

Leukemia inhibitory factor (LIF) exerts an oncogenic function in several types of cancer, including hepatocellular carcinoma (HCC). However, small-molecule inhibitors of LIF haven't been …

Jan 1, 2026 · The steroidal alkaloid cyclovirobuxine D (CVB-D), which is extracted from Buxus microphylla, has garnered increasing attention for its potential in anti-tumor research. Despite …

Aug 5, 2025 · Despite the growing number of studies on the oncogenicfunctionofLIFindifferenttumors,thecarcinogenic roleofLIFinHCCremainsunclear.

May 24, 2025 · Inhibiting LIF could suppress proliferation and metastasis by activating p38MAPK/p62‐modulated mitophagy. Interestingly, we found that the natural small‐molecule …

In summary, we identified LIF as a tumor promoter in HCC and systematically investigated its oncogenic role in facilitating cancer cell growth and metastasis by modulating mitophagy …

May 24, 2025 · Inhibiting LIF could suppress proliferation and metastasis by activating p38MAPK/p62‐modulated mitophagy. Interestingly, we found that the natural small‐molecule …