Scientists have created a model to study the role of RNA splicing defects in Alzheimer's disease, revealing degeneration and toxicity caused by neuron hyperexcitability. Researchers have puzzled over ...

This is a preview. Log in through your library . Abstract We have recently shown that discrete foci are present in the nuclei of mammalian cells in which each of the U1, U2, U4/U6, and U5 snRNPs ...

PHILADELPHIA - When most genes are transcribed, the nascent RNAs they produce are not quite ready to be translated into proteins - they have to be processed first. One of those processes is called ...

In multicellular organisms, the earliest products of transcription, called pre-mRNAs, undergo a molecular makeover before shipping out to the cytoplasm, where the modified mRNAs spell out the recipe ...

(Memphis, Tenn.—October 13, 2022) Researchers have puzzled over the neurodegenerative disorder Alzheimer’s disease for decades, but treatments to stop or reverse the disease’s effects on the brain ...

Researchers have puzzled over the neurodegenerative disorder Alzheimer's disease for decades, but treatments to stop or reverse the disease's effects on the brain have remained elusive. Scientists at ...