"Understanding how the loss of this LUC7 protein in some AMLs alters splicing could help in the design of therapies that exploit these splicing differences to treat AML," Burge says. "There are also ...

U1 adaptors offer an alternative to siRNA for targeted gene knockdown. You have full access to this article via your institution. The U1 small nuclear ribonucleoprotein particle (snRNP) comprises the ...

There are always exceptions to a rule, even one that has prevailed for more than three decades, as demonstrated by a new study on RNA splicing, a cellular editing process. The rule-flaunting exception ...

There are always exceptions to a rule, even one that has prevailed for more than three decades, as demonstrated by a Cold Spring Harbor Laboratory (CSHL) study on RNA splicing, a cellular editing ...

Scientists have created a model to study the role of RNA splicing defects in Alzheimer's disease, revealing degeneration and toxicity caused by neuron hyperexcitability. Researchers have puzzled over ...

Researchers believe they have discovered a new type of "tangle" in the Alzheimer’s brain: aggregates chock-full of RNA splicing machinery. Problems in RNA processing repeatedly surface in motor neuron ...

Alternative splicing contributes significantly to human proteome complexity and explains the numerical disparity between the low number of human protein-coding genes and the number of human proteins.

WHEN WE HUMANS got a first glimpse of our genome, we had good reason to question our biological complexity. Many scientists predicted we would possess some 100,000-plus genes, but sequencers finally ...

CAMBRIDGE, MA -- RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don’t code for proteins, called ...

(Memphis, Tenn.—October 13, 2022) Researchers have puzzled over the neurodegenerative disorder Alzheimer’s disease for decades, but treatments to stop or reverse the disease’s effects on the brain ...

Researchers have puzzled over the neurodegenerative disorder Alzheimer's disease for decades, but treatments to stop or reverse the disease's effects on the brain have remained elusive. Scientists at ...