Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...
The compositional complexity of the spliceosome creates a serious obstacle for its experimental analysis. Purification of a compositionally defined splicing complex C capable of completing the second ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 48 (November 29, 2022), pp. 1-12 (12 pages) Spliceosome activation is the process of creating the ...
In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...
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Understanding the Complex Architecture of the Minor Spliceosome
In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...
Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten -- ...
A post-splicing complex deposited upstream of each exon-exon junction tags mRNAs for nuclear export and mRNA surveillance. The pre-mRNA is coated with hnRNP proteins. The Spliceosome deposits an ...
Aided by two molecular control factors, the spliceosome rejects pre-mRNA that could be incorrectly spliced. While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome, which ...
Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA, ...
After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...
The Plant Cell, Vol. 27, No. 12 (December 2015), pp. 3294-3308 (32 pages) Plant SR45 and its metazoan ortholog RNPS1 are serine/arginine-rich (SR)-like RNA binding proteins that function in ...
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