Perhaps no topic is hotter in Alzheimer disease molecular research today than the synaptic effects of amyloid-β (Aβ) oligomers. These toxic assemblies disrupt synaptic function, and are leading ...
The regeneration of a signaling molecule, phosphatidylinositol 4,5 bisphosphate (PIP2), is not as simple as it was thought to be. Experimental work and mathematical modelling show that the decades-old ...
PIP2 is an important phosphoinositide that is present in around 1% of the plasma membrane. It is also involved in signal transduction of intracellular and extracellular components. There are two ...
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