Figure 1: Talin is required in the follicle cells for oocyte localization. Large clones of talin-mutant follicle cells induced a second phenotype: the formation of compound egg chambers that contain ...

The inside-out signaling of integrins regulates the ligand-binding affinity of the cell surface receptors in response to changes in the environment for cell survival. The specific binding to the ...

Researchers at Tampere University, Finland, have published new results in collaboration with an international research network that help to understand the biological phenomena mediated by cell ...

At last, the researchers have defined the molecular basis of the cell membrane in integrin activation. Scripps Research scientists have uncovered the workings of a critical process in cell survival.

PHILADELPHIA (May 28, 2025) — Talin is a protein that plays an important role in the immune system by activating integrins, receptors that help cells attach to one another. Now a new study by Fox ...

Integrin-dependent adhesion sites consist of clustered integrins that transmit mechanical forces and provide signaling required for cell survival and morphogenesis. Despite their importance, the ...

Living cell migration is regulated by the engagement of a force transmitter composed of vinculin and talin, two types of cytoskeletal protein, researchers have discovered. They showed that ...

Researchers at Tampere University, Finland, have published new results in collaboration with an international research network that help to understand the biological phenomena mediated by cell ...

Integrins are heterodimeric (αβ) cell surface receptors that are potential therapeutic targets for a number of diseases. Despite the existence of structural data for all parts of integrins, the ...

Insight into how molecular machines perform their biological functions depends on knowledge of the spatial organization of the components, their connectivity, geometry, and organizational hierarchy.

Genetically altered SHANK proteins are linked to autism. A new study shows SHANKs play a powerful, unexpected role in cancer as well. SHANK regulates adhesion and protrusion in cancer cells and ...

Scripps Research scientists have uncovered the workings of a critical process in cell survival. Their study, published recently in the Proceedings of the National Academy of Sciences, is the first to ...